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Intralesional therapy is the workhorse of keloid treatment, but the syringe can hold more than one drug. Here is how triamcinolone, 5-fluorouracil, and their combination compare on mechanism, evidence, and side effects.
August 8, 2026 · Ifeoma Stanfield
Intralesional triamcinolone is the workhorse of keloid treatment, but recurrence rates are stubbornly high. Here is what the drug actually does inside a scar, why it fails, and how combination protocols are changing the math.
August 7, 2026 · Ifeoma Stanfield
Intralesional triamcinolone has been the default keloid injection for decades, but 5-fluorouracil is increasingly used alongside or instead of it. Here is how each drug works, what the trials show, and why many clinicians now combine them.
August 7, 2026 · Ifeoma Stanfield
The full record
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ExplainerIntralesional injections remain the workhorse of keloid care, but triamcinolone and 5-fluorouracil work through very different mechanisms. Here is what the evidence says about choosing between them, and why many clinicians now combine the two.
· Ifeoma Stanfield
Myth CheckSurgery alone has a recurrence rate that can exceed 50 percent, but the full story is about wound biology, not a cursed scar. Here is what the evidence actually says about excision, and why adjuvant therapy changes the math.
· Ifeoma Stanfield
ExplainerIntralesional triamcinolone has been the default keloid injection for decades. Adding low-dose 5-fluorouracil changes the math on flattening, recurrence, and side effects. Here is how the two approaches actually compare.
· Ifeoma Stanfield
ExplainerIntralesional triamcinolone remains the workhorse of keloid treatment. Here is the mechanism, the realistic response rates, the side effects nobody warns you about, and why combining it with 5-fluorouracil has changed the math.
· Ifeoma Stanfield
ExplainerBoth drugs are injected into scar tissue, both have decades of use, and both fail in predictable ways. Here is how they work at the cellular level, and why many clinicians now combine them.
· Ifeoma Stanfield
ExplainerIntralesional triamcinolone is the workhorse of keloid treatment, yet response rates vary widely. A closer look at the mechanism explains the gap, and why combination protocols are becoming the standard of care.
· Ifeoma Stanfield
§ 04 · Frequently Asked
Intralesional corticosteroid injection (typically triamcinolone) remains the standard first-line treatment for most keloid scars.
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